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dc.contributor.authorQuan, Zhilong
dc.contributor.authorLuo, Chunyang
dc.contributor.authorZhu, Bitong
dc.contributor.authorZhao, Chungui
dc.contributor.authorYang, Mingyi
dc.contributor.authorBjørås, Magnar
dc.contributor.authorZhu, Kaizheng
dc.contributor.authorKjøniksen, Anna-Lena
dc.identifier.citationRSC Advances. 2021, 11 (17), 10121-10129.en_US
dc.description.abstractAntibiotic resistance is an emerging threat to public health. The development of a new generation of antimicrobial compounds is therefore currently required. Here we report a novel antimicrobial polymer of chitosan/polypropylene carbonate nanoparticles (CS/PPC NPs). These were designed and synthesized from readily available chitosan and a reactive oligomer polypropylene carbonate (PPC)-derived epoxy intermediate. By employing a simple and efficient functionalized strategy, a series of micelle-like chitosan-graft-polypropylene carbonate (CS-g-PPC) polymers and chitosan–polypropylene carbonate (CS–PPC) microgels were prepared by reacting mono-/bis-epoxy capped PPC with chitosan. The chemical structure, particle size, and surface charge of the newly synthesized polymers were characterized by infrared (IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, dynamic light scattering (DLS), and zeta potential measurements. The antimicrobial activities of these nanoparticles were determined in both Gram-positive bacteria (S. aureus) and Gram-negative bacteria (E. coli). Minimum inhibitory concentration (MIC), the nanoparticle concentration needed to completely inhibit the bacterial growth, was found at 128 μg mL−1 to 1024 μg mL−1, strongly depending both on the nature of the epoxy-imine network formed from the functional groups (mono- or bis-capped epoxy groups reacting with amine groups) and the feed ratio of the functional groups (-epoxy/-NH2) between the functionalized PPC and chitosan. No hemolysis was observed at concentrations well in excess of the effective bacteria-inhibiting concentrations. These findings provide a novel strategy to fabricate a new type of nanoantibiotic for antimicrobial applications.en_US
dc.publisherRoyal Society of Chemistryen_US
dc.rightsAttribution 3.0 Unported (CC BY 3.0)
dc.titleSynthesis and antimicrobial activities of chitosan/polypropylene carbonate-based nanoparticlesen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holder© 2021 The Author(s).en_US
dc.subject.nsiVDP::Teknologi: 500::Kjemisk teknologi: 560::Farmasøytisk formulering og teknologi: 568en_US
dc.subject.nsiVDP::Matematikk og Naturvitenskap: 400::Kjemi: 440::Legemiddelkjemi: 448en_US
dc.source.journalRSC Advancesen_US

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Attribution 3.0 Unported (CC BY 3.0)
Except where otherwise noted, this item's license is described as Attribution 3.0 Unported (CC BY 3.0)