Vis enkel innførsel

dc.contributor.authorNeyer, Sabrina E.
dc.contributor.authorWitthöft, Michael
dc.contributor.authorCropley, Mark
dc.contributor.authorPawelzik, Markus
dc.contributor.authorSütterlin, Stefan
dc.contributor.authorLugo, Ricardo Gregorio
dc.date.accessioned2023-01-18T15:45:06Z
dc.date.available2023-01-18T15:45:06Z
dc.date.created2022-09-21T13:55:36Z
dc.date.issued2022
dc.identifier.citationFrontiers in Neuroscience. 2022, 16, Artikkel 952903.en_US
dc.identifier.issn1662-4548
dc.identifier.urihttps://hdl.handle.net/11250/3044413
dc.description.abstractThe cortisol awakening response is a non-invasive biomarker for hypothalamic-pituitary-adrenal axis (HPA) dysregulation, reflecting accumulated stress over time. In a previous study we reported that a blunted CAR before an inpatient treatment predicted self-reported depressive symptoms six weeks and six months after discharge (XXXXXXXXX et al., 2019). This replication study adopted an improved overall methodology with more stringent assessment protocols and monitoring. The longitudinal design included 122 inpatients from a psychosomatic hospital with a diagnosis of Major Depression Disorder displaying symptoms of moderate to severe major depression (n=80 females). The Cortisol awakening response (CAR) was measured at intake. Depression severity was assessed as Beck Depression Inventory II scores at intake, discharge, six weeks and six months following discharge. Results from the original study were replicated in terms of effect size but did not reach statistical significance (correlation between BDI-II 6 months after discharge and AUCg: r=-.213; p=.054). The replication study yielded nearly identical correlation coefficients as in the original study (BDI-II 6 months and CAR, r=-.223, p<.05). The replication of previously reported effect sizes with a concurrent lack of statistical significance in the more restrictive, larger and better controlled replication study may well inform research on psycho-endocrinological predictors for treatment success, but suggests a rather limited practical relevance for cortisol awakening response measures in this clinical context.en_US
dc.language.isoengen_US
dc.publisherFrontiers Media S.A.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.subjectcortisol awakening responseen_US
dc.subjectdepressionen_US
dc.subjectHPA axisen_US
dc.subjectbiomarkeren_US
dc.subjectfollow-upen_US
dc.subjectreplication studyen_US
dc.titleThe cortisol awakening response at admission to hospital predicts depression severity after discharge in major depressive disorder patients—A replication studyen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2022 Neyer, Witthöft, Cropley, Pawelzik, Sütterlin and Lugo.en_US
dc.subject.nsiVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Psykiatri, barnepsykiatri: 757en_US
dc.source.volume16en_US
dc.source.journalFrontiers in Neuroscienceen_US
dc.identifier.doi10.3389/fnins.2022.952903
dc.identifier.cristin2053955
dc.source.articlenumber952903en_US
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Navngivelse 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Navngivelse 4.0 Internasjonal