dc.contributor.author | Frigstad, Svein Oskar | |
dc.contributor.author | Høivik, Marte Lie | |
dc.contributor.author | Jahnsen, Jørgen | |
dc.contributor.author | Småstuen, Milada Cvancarova | |
dc.contributor.author | Grimstad, Tore | |
dc.contributor.author | Berset, Ingrid Prytz | |
dc.contributor.author | Huppertz-Hauss, Gert | |
dc.contributor.author | Hovde, Øistein | |
dc.contributor.author | Bernklev, Tomm | |
dc.contributor.author | Moum, Bjørn | |
dc.contributor.author | Jelsness-Jørgensen, Lars-Petter | |
dc.date.accessioned | 2020-01-13T13:22:42Z | |
dc.date.available | 2020-01-13T13:22:42Z | |
dc.date.created | 2020-01-02T09:29:55Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 2072-6643 | |
dc.identifier.uri | http://hdl.handle.net/11250/2636015 | |
dc.description.abstract | Pain and vitamin D deficiency are common in inflammatory bowel disease (IBD). Disease activity, fatigue, frequent relapses, prior surgery and psychological factors all seem to influence the experience of pain in IBD. Vitamin D deficiency has been associated with muscle and skeletal pain. This study aimed to determine whether there is an association between vitamin D deficiency and severity of pain in patients with IBD, and to investigate the influence of other socio-demographic and psychological variables on the experience of pain. Methods: Patients with IBD were recruited from nine hospitals in Norway in a multicenter cross-sectional study. The Brief Pain Inventory (BPI) questionnaire was used to measure pain. Disease activity was assessed using clinical disease activity indices, C-reactive protein (CRP) and fecal calprotectin. Regression models were fitted to explore a possible association between 25-hydroxyvitamin D and pain severity. Results: Of 407 patients included in the analyses, 229 (56%) had Crohn's disease (CD) and 178 (44%) had ulcerative colitis (UC). Vitamin D deficiency was present in half (203/407) of patients. Presence of pain was reported by 76% (309/407). More severe pain was associated with female gender and increased disease activity scores, but not with increased CRP or fecal calprotectin. In CD, patients without prior intra-abdominal surgery reported more severe pain. In multivariate analyses, there was no association between 25-hydroxyvitamin D and pain severity. Conclusions: In this study, no significant association between pain severity and vitamin D deficiency was revealed in patients with IBD. | |
dc.language.iso | eng | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Pain Severity and Vitamin D Deficiency in IBD Patients | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | |
dc.source.volume | 12 | nb_NO |
dc.source.journal | Nutrients | nb_NO |
dc.source.issue | 1 | nb_NO |
dc.identifier.doi | 10.3390/nu12010026 | |
dc.identifier.cristin | 1764879 | |
cristin.unitcode | 224,0,0,0 | |
cristin.unitname | Høgskolen i Østfold | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |